This article lists the various anime conventions that are held in the Midwestern region of the United States. The states and areas included in this region are: Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, Ohio, South Dakota, and Wisconsin.

Illinois

Anime Central [Rosemont, Illinois]
Website: https://www.acen.org/
Anime Central includes panels and workshops, video gaming, table top and collectable card gaming, an art show and artist's alley, a cosplay contest, and more.


Indiana

Ikasucon [Fort Wayne, Indiana]
Website: https://www.ikasucon.org/
Ikasucon includes anime screenings, an AMV contest, guest panels, fan panels, workshops, cosplay events, an artists' alley, a dance, karaoke, video gaming, collectable card games, role playing games, tabletop games, a dealers' room, and more.


Iowa

AnimeIowa [Coralville, Iowa]
Website: https://www.animeiowa.com/
AnimeIowa features anime screenings, an AMV contest, guest panels, fan panels, workshops, cosplay contests, an art show and auction, an artists' alley, a dance, karaoke, video gaming, collectable card games, role playing games, tabletop games, a dealers' room, and more.


Kansas

Anime Festival Wichita [Wichita, Kansas]
Website: https://www.afwcon.org/
Anime Festival Wichita includes anime screenings, an AMV contest, guest panels, cosplay contests, an artists' alley, a dance karaoke, video gaming, collectable card games, role playing games, a dealers' room, and more.


Michigan

Youmacon [Troy, Michigan]
Website: https://www.youmacon.com/
Youmacon includes panels, a video room, cosplay, an artists' alley, gaming, an anime music video contest, a dealers' room, and more.


Minnesota

Anime Detour [Bloomington, Minnesota]
Website: https://www.animedetour.com/
Anime Detour has an art show, art auction, dealers' room, console and arcade games, card and board games, panels, workshops, events, an anime music video contest and showcase, cosplay, video rooms, and more.

Minneapolis Anime Convention [Minneapolis, Minnesota]
Website; https://www.kakkoicon.com/
The Minneapolis Anime Convention (M.A.C.) includes demonstrations of various aspects of Japanese society, a wide range of panels for both the Japanese and American sides of the anime industry, musical performances from bands and DJs, gaming, contests, and more.


Missouri

Anime St. Louis [St. Louis, Missouri]
Website: https://animestl.com/
Anime St. Louis features panels, an anime room, artists' alley, a cosplay contest, an anime music video contest, video games, tabletop role-playing games, card games, live action role playing games, a musical guest concert, dance parties, and a dealers' room.


Nebraska

Anime NebrasKon [Lincoln, Nebraska]
Website: https://www.animenebraskon.com/
Anime NebrasKon includes panels, an anime music video contest, cosplay, a dealers' room, and more.

Otaku Omaha [Omaha, Nebraska]
Website: https://www.otakuomaha.com/
Otaku Omaha features panels, video rooms, cosplay, video gaming, an artists' alley, an anime music video contest, a dealers' room, and more.


Ohio

Animarathon [Bowling Green, Ohio]
Website: https:// www.bgsu.edu/studentlife/organizations/anime/animarathon/
Animarathon is a convention put on by Anime in Northwest Ohio, the official anime club at Bowling Green State University. The convention includes multiple screening rooms of anime, panels, cosplay and video game competitions, and a dealers' room.

Anime Punch! [Columbus, Ohio]
Website: https://www.animepunch.org/
Anime Punch! features panels, cosplay, an anime music video contest, video rooms, video games, an artists' alley, karaoke, a dance, and a fanfiction contest.

Cleveland Colossal Convention [Beachwood, Ohio]
Website: https://www.colossalcon.com
The Cleveland Colossal Convention features screenings, cosplay, video gaming, and more.

Ohayocon [Columbus, Ohio]
Website: https://www.ohayocon.org/
Ohayocon includes panels and workshops, screenings, cosplay, an artists' alley, gaming, a dealers' room, and more.


South Dakota

Sogen Con [Sioux Falls, South Dakota]
Website: https://sogencon.org/
Sogen Con includes anime and AMV screenings, guest panels, fan panels, workshops, cosplay competitions, an art show, and artists' alley, a concert, a dance, video gaming, collectable card games, role playing games, a dealers' room, and more.


Wisconsin

Anime Milwaukee [Milwaukee, Wisconsin]
Website: https://www.animemilwaukee.com/
Anime Milwaukee is a convention hosted by the Japanese Animation Association of Milwaukee. The convention includes panels, anime viewing rooms, gaming, cosplay, and an anime music video contest.