Takuji Endo has served as an animator and director in the anime industry. Endo began his career as an animator at Toei Animation. He would later leave Toei and work for Madhouse, where he helped work on several notable anime releases.

One of Endo's earliest credits is serving as an assistant director on the Spirit Warrior OAV from 1988. Endo also worked on Record of Lodoss War. Endo directed Zetsuai 1989, a classic boys-love anime from 1992, as well as on 1993's Oshare Kozou wa Hanamaru video.

In 1994, Takuji Endo served as the director on the third episode of Phantom Quest Corp. That same year, he also served as an assistant director on Street Fighter II: The Movie. In 1999, Endo served as an assistant director on Reign: The Conqueror.

Endo continued to work at the turn of the millennium. In 2001, he served as an Animation Director on the OVA version of X. In 2002, Endo directed the eleventh episode of the Space Pirate Captain Harlock: The Endless Odyssey OVA. That same year, he also served as an Animation Director on Patlabor WXIII, the third film in the Patlabor anime franchise. In 2003, Endo served as a Technical Director for the Texhnolyze anime series.

In 2004, Takuji Endo served as a Unit Director on some of the episodes of the Paranoia Agent anime series. In 2006, Endo worked on Tokyo Tribe 2. This was followed by serving as a Visual Director for Highlander: The Search for Vengeance in 2007. One of his most recent anime credits was serving as a director for Stitch!, which is an anime spinoff series of Disney's film, Lilo & Stitch. In 2009, Takuji Endo co-directed the opening animation for Otakon 2009 with Yoshinori Kanemori.

On July 10, 2009, Cindy H. Yamauchi, a colleague of Takuji Endo, posted in her blog that Endo had passed away on July 8, 2009 from a sudden illness. She mentioned in her blog that Takuji Endo was in Korea at the time of his passing, working on the Stitch! anime series. Yamauchi worked with Takuji Endo on Record of Lodoss War and Tokyo Tribe 2. Yamuchi described Endo as cynical, sarcastic, and intelligent. She also said he had a "twisted sense of humor." Yamauchi went on to say that while no one Takuji Endo woked with would have called him a "pleasant guy," they can't deny the fact he was a "real pro."